In My Sister’s Keeper, Kate Fitzgerald (Sofia Vassilieva) is diagnosed with acute promyelocytic leukemia when she is two years old, and the prognosis is not positive. Her parents, Sara (Cameron Diaz) and Brian (Jason Patric), and her brother Jesse (Evan Ellingson) are not genetic matches. Sara, at least, will do anything to save Kate, and Dr Wayne (Jeffrey Markle) suggests, off the record, that producing another child in a test-tube would provide a perfectly matched donor. Anna (Abigail Breslin) is the result. The initial expectation is that only the blood from the umbilical cord will be used, but by the time Anna is 11, she’s undergone a number of medical procedures, including bone marrow transplants, and the latest call is for a kidney.